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Title:
LYSINE DERIVATIVE
Document Type and Number:
Japanese Patent JPS5690046
Kind Code:
A
Abstract:

NEW MATERIAL:A lysine derivative of formula I and an acid addition salt thereof.

EXAMPLE: The compound of formula II.

USE: A phage inhibitor capable of preventing the damage by the phage infection in the fermentation industry. 10-3W10-6M the derivative is added to a culture medium in the amino acid fermentation, e.g. L-lysine or L-glutamic acid, the nucleic acid fermentation, e.g. inosine or guanosine, and the organic acid fermentation, e.g. citric acid or lactic acid.

PROCESS: An active ester of azelaic acid is condensed with ethyl ester of lysine having a protected -amino group, and the protecting group is removed to give the compound of formula I. The active ester of the azelaic acid is obtained by reacting azelaic acid with n-hydroxysuccinimide and dicyclohexylimide in an inert solvent under cooling in ice.


Inventors:
KONDOU MICHIO
MURATA AKIRA
Application Number:
JP16735579A
Publication Date:
July 21, 1981
Filing Date:
December 21, 1979
Export Citation:
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Assignee:
AJINOMOTO KK
International Classes:
A01N37/46; A01N37/18; C07C67/00; C07C231/00; C07C233/47; (IPC1-7): A01N37/18; C07C103/48



 
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