Title:
MAST2 high affinity polypeptide and its use
Document Type and Number:
Japanese Patent JP6344767
Kind Code:
B2
Abstract:
The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, said polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions comprising the same. The invention is also directed to the use of said polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.
Inventors:
Purhau, Christoph
Lafon, Monique
Wolf, Nicholas
Khan, Zaki
Terry Anne, Eloane
Bitley, sandline
Lafon, Monique
Wolf, Nicholas
Khan, Zaki
Terry Anne, Eloane
Bitley, sandline
Application Number:
JP2014540443A
Publication Date:
June 20, 2018
Filing Date:
November 07, 2012
Export Citation:
Assignee:
INSTITUT PASTEUR
Center National Dolchersche Scientific
Universite Pierre Emery Curie (Paris Cigem)
Center National Dolchersche Scientific
Universite Pierre Emery Curie (Paris Cigem)
International Classes:
C12N15/09; A61K35/76; A61K38/16; A61K48/00; A61P25/00; A61P25/02; C07K14/145; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/01
Domestic Patent References:
| JP2012522831A | ||||
| JP2015501143A |
Attorney, Agent or Firm:
Kurata Masatoshi
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