To provide a method for producing optically active α-trifluoromethyllactic acid and its chiral ester, and to provide a method for purifying the compound (method for improving optical purity).
This method for producing the optically active α-trifluoromethyllactic acid and its chiral ester comprises asymmetrically hydrolyzing a racemic α-trifluoromethyllactate represented by the general formula (I) (R is a substituted or non-substituted 1 to 12C hydrocarbon group) in the presence of an enzyme, an enzyme-immobilized product, a microbial cell culture solution or a microbial cell-treated product. The method for purifying the compound comprises recrystallizing the optically active α-trifluoromethyllactic acid obtained by the method.
COPYRIGHT: (C)2007,JPO&INPIT
ENOMOTO KANEHIKO
URAGAKI TOSHITAKA
Ishii Teiji