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Title:
MMP-9の調節剤およびその使用
Document Type and Number:
Japanese Patent JP2010536744
Kind Code:
A
Abstract:
A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises containing the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.

Inventors:
Egret, Irit
Gabriel Rosenblum
Application Number:
JP2010520682A
Publication Date:
December 02, 2010
Filing Date:
August 07, 2008
Export Citation:
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Assignee:
YEDA RESEARCH AND DEVELOPMENT COMOPANY LIMITED
International Classes:
A61K45/00; A61P11/00; A61P11/08; A61P13/12; A61P17/00; A61P19/02; A61P21/00; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P35/04; A61P43/00; G01N33/15; G01N33/50
Other References:
JPN6013005114; Borkakoti N.: 'Matrix metalloproteases: variations on a theme.' Prog Biophys Mol Biol. Vol.70 No.1, 1998, pp.73-94
JPN6013005115; Atkinson JJ and Senior RM.: 'Matrix metalloproteinase-9 in lung remodeling.' Am J Respir Cell Mol Biol. Vol.28 No.1, 200301, pp.12-24
JPN6013005111; Van den Steen PE et al.: 'The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and' J Biol Chem. Vol.281 No.27, 20060503, pp.18626-18637
JPN6013005113; シグマ抗体カタログ , 2001, p.380
JPN6013005114; Borkakoti N.: 'Matrix metalloproteases: variations on a theme.' Prog Biophys Mol Biol. Vol.70 No.1, 1998, pp.73-94
JPN6011026422; Winter G and Harris WJ: 'Humanized antibodies' Immunology Today Vol.14 no.6, 1993, pp.243-246
JPN6013005115; Atkinson JJ and Senior RM.: 'Matrix metalloproteinase-9 in lung remodeling.' Am J Respir Cell Mol Biol. Vol.28 No.1, 200301, pp.12-24
JPN6013005111; Van den Steen PE et al.: 'The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and' J Biol Chem. Vol.281 No.27, 20060503, pp.18626-18637
JPN6014007112; Delacourt C et al.: 'Imbalance between 95 kDa type IV collagenase and tissue inhibitor of metalloproteinases in sputum of' Am J Respir Crit Care Med. Viol.152 No.2, 199508, pp.765-774
JPN6014007113; Sorbi D et al.: 'Elevated levels of 92-kd type IV collagenase (matrix metalloproteinase 9) in giant cell arteritis.' Arthritis Rheum. Vol.39 No.10, 199610, pp.1747-1753
JPN6014007114; Vadillo-Ortega F et al.: '92-kd type IV collagenase (matrix metalloproteinase-9) activity in human amniochorion increases with' Am J Pathol. Vol.146 No.1, 199501, pp.148-156
Attorney, Agent or Firm:
Nobuaki Kazehaya
Noriko Asano