Title:
酸化鉄ナノ粒子に基づくリンパ系造影用ＭＲＩ造影剤およびこれを用いてリンパ節を造影する方法
Document Type and Number:
Japanese Patent JP5799161
Kind Code:
B2
Abstract:
Provided are a contrast agent for contrast imaging lymph node, which includes iron oxide nanoparticles dispersed and stabilized in an aqueous medium by a mussel adhesive protein-mimetic copolymer, a method for contrast enhanced lymphography using the foregoing contrast agent, and a method for diagnosis of lymph node cancers using the foregoing contrast agent. Using such a mussel adhesive protein-mimetic copolymer, the surface of iron oxide is modified and dispersed well in water to prepare a colloidal solution, which in turn forms the contrast agent containing the colloidal solution. The inventive contrast agent does not have toxicity and is easily taken up to the lymph node to exhibit excellent contrast imaging effects. The contrast agent of the present invention is useful for diagnosis of metastatic cancers.
Inventors:
Park Ju Yun
Myeong Wan Jae
John Bonn-Sik
Kim Eun Gyu
Kwon Eunbull
Hyuntaegu fan
Rin Daishun
Myeong Wan Jae
John Bonn-Sik
Kim Eun Gyu
Kwon Eunbull
Hyuntaegu fan
Rin Daishun
Application Number:
JP2014503614A
Publication Date:
October 21, 2015
Filing Date:
June 20, 2012
Export Citation:
Assignee:
HANWHA CHEMICAL CORPORATION
International Classes:
A61K49/00
Domestic Patent References:
| JP2191629A | ||||
| JP63023670A | ||||
| JP2011079781A | ||||
| JP10120597A |
Foreign References:
| US20090280063 | ||||
| EP2289553A1 |
Other References:
N.Engl.J.Med.,2003年,Vol.348,p.2491-2199
Acta Biomaterialia,2011年 3月,Vol.7,p.2518-2525
Hematology,2009年,p.720-726
Acta Biomaterialia,2011年 3月,Vol.7,p.2518-2525
Hematology,2009年,p.720-726
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi