Title:
好中球の接着および移動の遮断に有用なＭａｃ−１ Ｉ−ドメイン蛋白質
Document Type and Number:
Japanese Patent JPH09512426
Kind Code:
A
Abstract:
An isolated and purified protein of the I-Domain from the human leukocyte beta 2-integrin Mac-1, expressed in recombinant Escherichia coli as a soluble fusion protein with glutathione S-transferase (GST). The protein, a functional derivative, fragment, analog or chemical derivative of such fragment is useful in the treatment of inflammation by interfering with the cell adhesion mechanism to block adhesion and migration of neutrophils.
Inventors:
Anderson, Donald シイ
トミッチ, the Choi * Shen シイ
バジト * ジェシュケ, Mary El
Fairbanks, Michael ビイ
ヘインリクソン, Robert El
トミッチ, the Choi * Shen シイ
バジト * ジェシュケ, Mary El
Fairbanks, Michael ビイ
ヘインリクソン, Robert El
Application Number:
JP52767095A
Publication Date:
December 16, 1997
Filing Date:
April 19, 1995
Export Citation:
Assignee:
Pharmacia & Upjohn company
International Classes:
C12N15/09; A61K38/00; A61P29/00; C07K14/705; C07K14/78; C07K19/00; C12N1/21; C12P21/02; C12R1/19; (IPC1-7): C12N15/09; A61K38/00; C07K14/78; C07K19/00; C12N1/21; C12P21/02
Attorney, Agent or Firm:
Aoyama 葆 (besides two persons)