Title:
工学的生合成によるマクロラクタム
Document Type and Number:
Japanese Patent JP2010516282
Kind Code:
A
Abstract:
Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynthesis of the natural starter unit 3-amino-5-hydroxybenzoic acid has been deleted.
Inventors:
Gary Ashley
Hugo He Menselha
Janice Law Wee
John Earl Kearney
Hugo He Menselha
Janice Law Wee
John Earl Kearney
Application Number:
JP2009547288A
Publication Date:
May 20, 2010
Filing Date:
January 23, 2008
Export Citation:
Assignee:
Kosan Biosciences, Inc.
International Classes:
C12P13/00; A61K31/395; A61P35/00; A61P35/02; C07D225/06; C12N15/09
Domestic Patent References:
| JP2010509306A | 2010-03-25 |
Foreign References:
| WO2005061461A1 | 2005-07-07 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka