Title:
大環状化合物およびそれらの使用
Document Type and Number:
Japanese Patent JP7353281
Kind Code:
B2
Abstract:
The present invention provides novel compounds (e.g., compounds of Formulae (I), (II), (III), (IV)) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or pharmaceutically acceptable salts thereof, optionally in a pharmaceutically acceptable carrier, and a medical uses thereof.
Inventors:
Kishi, Yoshito
Kazunobu Kira
Ken Ito
Kazunobu Kira
Ken Ito
Application Number:
JP2020527111A
Publication Date:
September 29, 2023
Filing Date:
November 15, 2018
Export Citation:
Assignee:
President and Fellows of Harvard College
Eisai R&D Management Co., Ltd.
Eisai R&D Management Co., Ltd.
International Classes:
C07D493/22; A61K31/7048; A61K39/395; A61P35/00; A61P35/04; A61P43/00; C07H9/02
Foreign References:
| WO2016003975A1 |
Other References:
Angew. Chem. Int. Ed.,2017年,56,10796-10800
Tetrahedron Letters,1992年,Vol.33, No.12,1557-1560
Bioorg. Med. Chem.,2009年,17,2199-2203
Tetrahedron Letters,1992年,Vol.33, No.12,1557-1560
Bioorg. Med. Chem.,2009年,17,2199-2203
Attorney, Agent or Firm:
Kiyoshi Kuzuwa
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