Title:
マクロ環状化合物
Document Type and Number:
Japanese Patent JP5235859
Kind Code:
B2
Abstract:
The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof:
wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , L 1 , L 2 , and L 3 are as defined in the specification.
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Inventors:
Nobuo Shinma
Takuo Tsukuda
Hiroshi Oyano
Atsushi Suda
Tadakatsu Hayase
Junto Haneda
Kenichi Kawasaki
Ryo Komiyama
Naomi Ono
Toshikazu Yamazaki
Ryoichi Saito
Masami Kawauchi
Kiyoshi Hasegawa
Takuo Tsukuda
Hiroshi Oyano
Atsushi Suda
Tadakatsu Hayase
Junto Haneda
Kenichi Kawasaki
Ryo Komiyama
Naomi Ono
Toshikazu Yamazaki
Ryoichi Saito
Masami Kawauchi
Kiyoshi Hasegawa
Application Number:
JP2009501315A
Publication Date:
July 10, 2013
Filing Date:
February 29, 2008
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07D497/08; A61K31/529; A61K31/53; A61K31/5377; A61P1/16; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P19/02; A61P21/00; A61P25/00; A61P25/28; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C07D513/08; C07D513/18; C07D513/20; C07D515/08
Domestic Patent References:
| JP2005225787A | 2005-08-25 | |||
| JP2005530689A | 2005-10-13 |
Foreign References:
| WO2007058627A1 | 2007-05-24 | |||
| WO2007138994A1 | 2007-12-06 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto