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Title:
抗炎症活性を有するマクロライドコンジュゲート
Document Type and Number:
Japanese Patent JP4613366
Kind Code:
B2
Abstract:
The present invention relates to new compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure II: L represents the chain of the substructure III: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ -X 1 -(CH 2 ) m -Q-(CH 2 ) n -X 2 -€ƒ€ƒ€ƒ€ƒ€ƒ III D represents the steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity; The present invention relates also to pharmaceutically acceptable salts and solvates of such prepared compounds, to processe and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals.

Inventors:
Muraden Mercep
Milan Mesic
Linda Tomaskovich
Stribol Malkovich
Bosca Flavasic
Oresta Macalha
Visnya Polyac
Application Number:
JP2006506511A
Publication Date:
January 19, 2011
Filing Date:
April 23, 2004
Export Citation:
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Assignee:
GLAXO GROUP LIMITED
International Classes:
C07J43/00; A61K31/58; A61P1/00; A61P1/04; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/04; A61P19/06; A61P21/00; A61P27/02; A61P29/00; A61P31/04; A61P37/02; A61P37/08; A61P43/00; C07D273/00; C07D413/12; C07D473/04; C07H17/08; C07J1/00; C07J71/00; A61K31/395; A61K31/4427; A61K31/522; C07D267/00; C07D413/06; C07D473/08
Domestic Patent References:
JP1287076A
Foreign References:
WO2002055531A1
Other References:
COSTA, A. M.,Hybrids of macrolides and nucleobases or nucleosides,Tetrahedron Letters,2000年,41(18),p. 3371-3375
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Nishino Mitsuru
Mizuhara Masahiro