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Title:
MACROLIDE
Document Type and Number:
Japanese Patent JP2007254483
Kind Code:
A
Abstract:

To provide macrolides, especially macrolactam macrolides.

The new ascomycin compounds such as (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12[(1E)-2-[(1r,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-17,21-diethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,27-trimethyl-11,28-dioxa-4-azatricyclo-[22.3.1.04,9]octacosa-18-ene-2,3,10,16-tetraone are produced by fermentation or substitution of hydroxy with chloro and simultaneous or successive epimerization.

COPYRIGHT: (C)2008,JPO&INPIT


Inventors:
FLEISSNER GERHARD
HAECKER HELMUT
KUESTERS ERNST
PENN GERHARD
Application Number:
JP2007124376A
Publication Date:
October 04, 2007
Filing Date:
May 09, 2007
Export Citation:
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Assignee:
NOVARTIS AG
International Classes:
C07H15/04; A61K31/395; C12P17/16; A61K31/7052; A61P1/04; A61P3/10; A61P5/14; A61P11/06; A61P17/06; A61P17/14; A61P21/04; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P37/02; A61P37/06; A61P37/08; C07D498/18
Domestic Patent References:
JP2000505050A2000-04-25
JPH03223291A1991-10-02
JPS61148181A1986-07-05
JP4043239B
Foreign References:
WO1999042104A11999-08-26
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi



 
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