Title:
マラチオンカルボキシルエステラーゼ
Document Type and Number:
Japanese Patent JP4112617
Kind Code:
B2
Abstract:
The present invention provides an isolated DNA molecule encoding Malathion Carboxylesterase capable of hydrolysing at least one organophosphate selected from the group consisting of carboxylester organophosphates and dimethyloxon organophosphates. The DNA molecule comprises a nucleotide sequence having at least 60%, preferably at least 80% and more preferably at least 95% homology with Lc?E 7, in which the protein encoded by the DNA molecule differs from E 3 at least in the substitution of Trip at position 251 with an amino acid selected from the group consisting of Leu, Ser, Ala, Ile, Val, Thr, Cys, Met and Gly. The preferred substituents are Leu and Ser.
Inventors:
Russell, Robein Joyce
Richard Newcombe, Richard
Campbell, Peter Malcolm
Robin, Jeffrey Charles de Quetville
Charles, Claudian
Smith, Kelly-Anne
Voice, thomas mark
Oak Shot, John Graham
Brownlee, Jeremy Colin
Richard Newcombe, Richard
Campbell, Peter Malcolm
Robin, Jeffrey Charles de Quetville
Charles, Claudian
Smith, Kelly-Anne
Voice, thomas mark
Oak Shot, John Graham
Brownlee, Jeremy Colin
Application Number:
JP51923797A
Publication Date:
July 02, 2008
Filing Date:
November 22, 1996
Export Citation:
Assignee:
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION
International Classes:
A62D3/00; C12N15/09; A62D3/02; C02F1/00; C02F1/58; C02F3/00; C12N1/21; C12N5/00; C12N5/10; C12N9/16; C12N9/18; C12N15/55; C12S99/00; C12R1/91
Foreign References:
| WO1995019440A1 |
Other References:
Biochem. Genetics., 1994年, Vol.32 Nos.11/12 , p437-453
Biochem. Genetics., 1994年, Vol.32.Nos.1/2 , p9-24
Biochem. Genetics., 1994年, Vol.32.Nos.1/2 , p9-24
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Takashi Watanabe
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