Title:
MALEATE OF CYCLOBUTENE DERIVATIVE
Document Type and Number:
Japanese Patent JPH01113376
Kind Code:
A
Abstract:
NEW MATERIAL:1-Amino-2-{4-[3--(piperidinomethyl)phenoxy]-cis-2- butenylamino}-1-cyclobutene-3,4-dione.maleate shown by the formula. USE:An active ingredient for drug and anti-peptic ulcer. Having excellent characteristics of high solubility in water and body fluids such as gastric juice and intestinal juice and improved absorption efficiency (bioavailability) free from moisture absorption and effective for treating diseases such as peptic ulcer caused by excess gastric acid secretion, as an excellent H2 acceptor antagonist. PREPARATION:1-Amino-2-{4-[3-(piperidinomethyl)phenoxy]-cis-2-butenylam inie}-1- cyclobutene-3,4-dione is reacted with maleic acid in a solvent such as ethanol at room temperature to readily give a compound shown by the formula.
Inventors:
YAMATO EISAKU
TANI JUNICHI
MIZOBE MASAKAZU
HIRAKAWA YOSHIYUKI
NOHARA FUJIO
TANI JUNICHI
MIZOBE MASAKAZU
HIRAKAWA YOSHIYUKI
NOHARA FUJIO
Application Number:
JP27132787A
Publication Date:
May 02, 1989
Filing Date:
October 27, 1987
Export Citation:
Assignee:
TANABE SEIYAKU CO
IKEDA MOHANDO CO
IKEDA MOHANDO CO
International Classes:
C07D295/08; A61K31/445; A61P1/04; (IPC1-7): A61K31/445; C07D295/08
Attorney, Agent or Firm:
Shoji Nakajima