Title:
代謝調節剤として有用なマロニル-CoA脱炭酸酵素阻害剤
Document Type and Number:
Japanese Patent JP4267920
Kind Code:
B2
Abstract:
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
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Inventors:
Argenius Thomas
Chen Me
Cheng Chi Fay
Fan uchin
Nathan alex
Tis sobouchy
Wallace David
Liu Bin
Masahiro Nishimoto
Ropa Schuk Gary Dee.
Dick Jason Earl.
Chen Me
Cheng Chi Fay
Fan uchin
Nathan alex
Tis sobouchy
Wallace David
Liu Bin
Masahiro Nishimoto
Ropa Schuk Gary Dee.
Dick Jason Earl.
Application Number:
JP2002563930A
Publication Date:
May 27, 2009
Filing Date:
January 22, 2002
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07C279/18; C07D295/10; A61K31/04; A61K31/045; A61K31/12; A61K31/136; A61K31/145; A61K31/15; A61K31/155; A61K31/16; A61K31/167; A61K31/17; A61K31/18; A61K31/196; A61K31/197; A61K31/22; A61K31/223; A61K31/245; A61K31/27; A61K31/275; A61K31/341; A61K31/40; A61K31/41; A61K31/415; A61K31/4164; A61K31/42; A61K31/427; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4465; A61K31/454; A61K31/5375; A61K31/662; A61K31/664; A61P3/00; A61P3/04; A61P3/08; A61P3/10; A61P3/12; A61P9/00; A61P9/04; A61P9/10; A61P35/00; A61P43/00; C07C33/46; C07C49/82; C07C225/22; C07C233/33; C07C235/24; C07C235/84; C07C251/48; C07C251/86; C07C255/29; C07C255/57; C07C257/22; C07C307/10; C07C311/16; C07C335/18; C07D207/325; C07D211/04; C07D211/16; C07D211/22; C07D213/36; C07D213/53; C07D213/75; C07D231/06; C07D231/14; C07D231/38; C07D233/54; C07D233/64; C07D233/90; C07D257/04; C07D257/06; C07D261/04; C07D261/08; C07D261/14; C07D261/16; C07D261/18; C07D295/04; C07D295/12; C07D295/13; C07D295/18; C07D295/194; C07D295/21; C07D295/215; C07D295/22; C07D295/28; C07D307/52; C07D333/36; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D405/12; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07F9/24; C07F9/38; C07F9/40
Domestic Patent References:
| JP58018363A | ||||
| JP1502513A |
Foreign References:
| US4156016 | ||||
| US4432991 | ||||
| WO2001003705A1 | ||||
| WO1999018099A1 | ||||
| US5508400 | ||||
| WO2000054759A1 |
Attorney, Agent or Firm:
Hatsushi Shimizu