マンニッヒ塩基N-オキシド薬物 - Cascade Pro Drug Incorporated

Title:

マンニッヒ塩基N-オキシド薬物

Document Type and Number:

Japanese Patent JP5513135

Kind Code:

B2

Abstract:

Disclosed are Mannich base N-oxides of drugs containing acidic N—H groups. Pharmaceutical compositions comprising a therapeutically effective amount of Mannich base N-oxides, or a N-oxide rearrangement product, pharmaceutically acceptable salt or prodrug thereof, are also disclosed. Further, disclosed are methods of using the compounds, alone or in combination with one or more other active agents or treatments.

Inventors:

Keana John F. W.
Westberg Paul
Card John Gee.
Ralani Arshad El.

Application Number:

JP2009554553A

Publication Date:

June 04, 2014

Filing Date:

March 19, 2008

Export Citation:

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Assignee:

Cascade Pro Drug Incorporated

International Classes:

C07D405/04; A61K31/337; A61K31/445; A61K31/5377; A61K31/7072; A61K45/00; A61P1/00; A61P1/16; A61P9/00; A61P17/06; A61P19/02; A61P21/00; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C07D233/96; C07D307/04; C07D307/20; C07H19/067; C07H19/073; C07C291/04

Foreign References:

US4845081

Other References:

Sih, John C.; Wha bin Im; Robert, Andre; Graber, David R.; Blakeman, David P.,Studies on (H+-K+)-ATPase inhibitors of gastric acid secretion. Prodrugs of 2-[(2-pyridinylmethyl)sulfinyl]benzimidazole proton-pump inhibitors,Journal of Medicinal Chemistry ,1991年,34(3),1049-62
Koch, Suzanne A. M.; Sloan, Kenneth B.,N-Mannich-base prodrugs of 5-iodo-2'-deoxycytidine as topical delivery enhancers,Pharmaceutical Research ,1987年,4(4),317-20

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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