Title:
MANUFACTURE OF 1,3-OXIDATED 8 ALPHA-ESTRATRIENE
Document Type and Number:
Japanese Patent JPS5874697
Kind Code:
A
Abstract:
8alpha-Oestratrienes of formula (I) are new, (where X is O or R1 and R3 are H, acyl, (cyclo)-alkyl or a satd. O-contg. heterocyclic gp; R2 is lower alkyl; and R4 is H or opt. unsatd., (substd.) hydrocarbyl). (I) have potent vaginotropic but weak uterotropic properties, and are thus useful in the treatment of post-menopausal disorders caused by oestrogen insufficient. (I) may be administered orally or parentally in doses of 0.1-20 mg (pref. 0.05-5 mg). (I) are along intermediates for other pharmaceutically active steroids.
Inventors:
KURAUSU PURETSUEBUOBUSUKII
HENRII RAURENTO
HERUMUUTO HOOFUMAISUTERU
RUUDORUFU BUIIHERUTO
FURIITOMUNTO NOIMAN
YUKISHIGE NISHINO
HENRII RAURENTO
HERUMUUTO HOOFUMAISUTERU
RUUDORUFU BUIIHERUTO
FURIITOMUNTO NOIMAN
YUKISHIGE NISHINO
Application Number:
JP15899582A
Publication Date:
May 06, 1983
Filing Date:
September 14, 1982
Export Citation:
Assignee:
SCHERING AG
International Classes:
C07J1/00; A61K31/565; A61P13/02; A61P15/00; C07J41/00; C07J43/00; (IPC1-7): A61K31/565; C07J1/00
Attorney, Agent or Firm:
Toshio Yano
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