Title:
MANUFACTURE OF 33METHYLLDELTA33CEPHEMM44CARBOXYLIC ACID COMPOUND
Document Type and Number:
Japanese Patent JPS5598187
Kind Code:
A
Abstract:
3-Methylenecepham-4-carboxylic acids and esters of the Formula I and 3-methyl- DELTA 3-cephem-4-carboxylic acids and esters of the Formula II where R is hydrogen or an organic acyl group and R1 is hydrogen, C1-C4 alkyl a carboxylic acid protecting group or a pharmaceutically acceptable cation are prepared via the reductive displacement of a 3-substituted methyl cephalosporin of the Formula III where R2 is an organic residue such that -SR2 constitutes a reductively displaceable moiety, and R and R1 have the same meanings as defined in Formulae I and II, reductive displacement being accomplished by catalytic hydrogenation or chemical reduction. The 3-methylene cepham compounds are isomerized in dimethylacetamide in the presence of a tertiary alkyl amine to provide 3-methyl-7-acylamido- DELTA 3-cephem-4-carboxylic acids and esters.
Inventors:
ROBAATO REIMONDO CHIYOOBETSUTO
Application Number:
JP13169779A
Publication Date:
July 25, 1980
Filing Date:
October 12, 1979
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
A61K31/545; C07D499/00; C07D501/00; C07D501/02; C07D501/04; C07D501/14; C07D501/16; C07D501/18; C07D501/22; C07D501/60; C07F7/18; C07D; (IPC1-7): C07D501/04