Title:
メドロゲストンの製造
Document Type and Number:
Japanese Patent JP4015206
Kind Code:
B2
Abstract:
A process for the production of medrogestone, in which, in an intermediate step, the solvate 3β,5α,6β-trihydroxy-6α,17α-dimethylpregnan-20-one monomethanolate is obtained as a solid, stable compound by displacing the organic solvent from a solution of of 3β,5α,6β-trihydroxy-6α,17α-dimethylpregnan-20-one with a lower alkanol, and a Diels-Alder adduct of 6-methylene-17α-methylpregn-4-ene-3,20-dione with maleic anhydride is used as an intermediate for production of the corresponding dicarboxylic acid salt for removal of 6-methylene-17α-methylpregn-4-ene-3,20-dione contamination of the desired product. Another intermediate, 6β-hydroxy-6α,17α-dimethylpregn-4-ene-3,20-dione, has been found to prevent smooth muscle proliferation and is useful in the treatment of atherosclerosis and restinosis.
Inventors:
Michael William Winkle
Robert Dempster Mitchell
Robert Dempster Mitchell
Application Number:
JP10529895A
Publication Date:
November 28, 2007
Filing Date:
April 28, 1995
Export Citation:
Assignee:
Wyeth
International Classes:
C07J75/00; C07J7/00; C07J53/00; C07J71/00
Attorney, Agent or Firm:
Aoyama Aoi
Mitsuo Tanaka
Mitsuo Tanaka