MANUFACTURE OF ALPHA-HYDROXY ACID

Japanese Patent JPS61191649

A

The invention relates to a process for preparing alpha -hydroxy-acids of general formula: in which R represents hydrogen or a lower alkyl radical and Cy represents a phenyl, naphthyl or heterocyclic radical, these latter three radicals optionally comprising one or more substituents selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy radicals and halogen atoms, process which comprises the treatment of an alpha -monohalogenated ketone of general formula: in which R and Cy have the same meaning as above and X represents chlorine, bromine or iodine, in the presence of an aqueous solution of an alkali metal hydroxide, a non-polar organic solvent selected from an aromatic or alicyclic hydrocarbon and oxygen in excess optionally in the presence of an inert gas, the treatment being carried out at a temperature ranging from the boiling temperature of the reaction medium at atmospheric pressure and 240 DEG C. under pressure and the alkali metal so formed is then acidified to obtain the desired acid.

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JIYAN DANIERU ANDORE
PIEERU JIYAN GUROTSUSHI
ARAN EIMU
JIYOBANNI BENERUTSUCHI MANZARO

JP27058285A

August 26, 1986

November 29, 1985

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SANOFI SA
INDOUSUTORIA CHIM PURODOTSUTEI

C07C59/48; B01J23/00; C07B61/00; C07C51/00; C07C59/56; C07C67/00; C07D333/24; C07D521/00; (IPC1-7): B01J23/04; C07C51/00; C07C59/48; C07C59/56; C07D333/24; C07D521/00

Eiji Saegusa

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