Title:
MANUFACTURE OF AROMATIC AMINOCARBOXYLIC ACID ALKYL ESTER
Document Type and Number:
Japanese Patent JPS57150647
Kind Code:
A
Abstract:
1. A process for the manufacture of an aromatic aminocarboxylic acid lower alkyl ester from an aminocarboxylic acid of the general formula (I) see diagramm : EP0058924,P7,F1 in which W, X, Y and Z, being identical or different, each denotes hydrogen, fluoro, chloro, bromo, amino, nitro, cyano, carbamoyl, sulfamoyl, carboxy, trifluoromethyl, R'-, R'-O-, R'-O-CO, R'-CO-, R'-NH-, R'R"N- or R'-O-SO2 -, R' and/or R" being alkyl having from 1 to 10 carbon atoms, optionally substituted phenoxy, optionally substituted phenylazo, optionally substituted phenylcarbonylamino, optionally substituted phenoxamide or optionally substituted phenylcarbamoyl, the substituents being in each case alkyl and/or alkoxy each having from 1 to 10 carbon atoms, halogeno, carbamoyl and/or phenoxy optionally substituted by halogen, or in which two of W, X, Y and Z are ring atoms of a fused carboxyclic ring system of a fused N-, O- and/or S-containing heterocyclic ring system, which for their part may carry oxo functions, wherein said aminocarboxylic acid is esterified with a lower dialkyl sulfate in an aprotic, water-miscible, non-alkylating and non-alkylatable organic solvent in the presence of a basic compound, characterized by converting the aminocarboxylic acid into its carboxylic acid salt by means of an inorganic base and reacting the salt obtained in anhydrous medium through dropwise or continual addition of the dialkyl sulfate, or by initially introducing the aminocarboxylic acid together with the dialkyl sulfate and then reacting the mixture through dropwise or continual addition of an organic base in an anhydrous reaction medium.
Inventors:
YURUGEN HOON
KURAUSU FUNGERU
KURAUSU FUNGERU
Application Number:
JP2367882A
Publication Date:
September 17, 1982
Filing Date:
February 18, 1982
Export Citation:
Assignee:
HOECHST AG
International Classes:
C07C67/00; C07C227/00; C07C227/18; C07C229/54; C07C229/62; C07C229/64; C07C237/30; C07D235/26; C07D241/44; C07D241/52; (IPC1-7): C07C99/00; C07C101/52; C07C101/66; C07C101/68; C07C101/72; C07C103/76; C07D235/26; C07D241/44
Domestic Patent References:
| JPS54148713A | 1979-11-21 |