Title:
MANUFACTURE OF CARBAPENEM INTEMEDIATE
Document Type and Number:
Japanese Patent JPS61215367
Kind Code:
A
Abstract:
A process for the preparation of a 4-[3-carboxy-3-diazo-2-oxopropyl]azetidin-2-one of the formula comprising reacting a 4-acetoxy-2-azetininone of the formula with a compound of the formula in an inert solvent, in the presence of a base and of a silylating agent, in a one-pot process. Many of the products are new. The products are useful in the synthesis of carbapenem antibiotics.
Inventors:
DEIITAA HEBITSUHI
BORUFUGANGU HARUTOBITSUHI
BORUFUGANGU HARUTOBITSUHI
Application Number:
JP5963986A
Publication Date:
September 25, 1986
Filing Date:
March 19, 1986
Export Citation:
Assignee:
BAYER AG
International Classes:
C07D205/08; C07D205/085; C07D209/48; C07D403/12; C07D409/04; C07D409/06; C07D409/14; C07D411/04; C07D411/14; C07D477/00; C07D477/04; C07D499/06; C07D521/00; C07F7/18; C07F9/40; (IPC1-7): C07D205/00; C07D205/08; C07D209/00; C07D209/48; C07D257/00; C07D403/12; C07D487/04; C07D521/00
Attorney, Agent or Firm:
Heiyoshi Odashima
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