Title:
MANUFACTURE OF D-2-SUBSTITUTED-6-ALKYL-8- SUBSTITUTED ERGOLINE AND RELATED COMPOUNDS
Document Type and Number:
Japanese Patent JPS5888379
Kind Code:
A
Abstract:
1451724 D - 2 - substituted - 8 - substituted ergoline derivatives ELI LILLY CO 5 Feb 1974 [28 Nov 1973] 05346/74 Addition to 1423065 Heading C2C Novel ergoline derivatives of the Formula II wherein X is Cl, Br, I, CH 3 or CN, R is CH 2 CN or CH 2 CONH 2 , and R1 is C 2-4 primary alkyl, or a radioactive C 14 methyl group and pharmaceutically acceptable acid-addition salts thereof may be prepared by demethylation of the corresponding 6-methyl ergoline to give the 6-unsubstituted ergoline II and then alkylation at the 6-position. Pharmaceutical compositions of the compounds II are prolactin inhibitors.
More Like This:
| JPS58152884 | ERGOT ALKALOIDS |
| JPS52131600 | IMPROVEMENT IN ORGANIC COMPOUND |
Inventors:
JIEEMUZU AREN KUREMENSU
EDOMUNDO KAARU KOONFUERUDO
NIKORASU JIEEMUZU BATSUCHI
EDOMUNDO KAARU KOONFUERUDO
NIKORASU JIEEMUZU BATSUCHI
Application Number:
JP19068482A
Publication Date:
May 26, 1983
Filing Date:
October 29, 1982
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
C07D457/02; A61K31/41; A61K31/48; C07D401/02; C07D401/04; C07D401/10; C07D457/00; C07D457/04; C07D471/02; C07D471/06; C07D519/02; C07G5/00; A61K; C07D; (IPC1-7): C07D457/02
Attorney, Agent or Firm:
Kiyoshi Inomata