Title:
植物培養での高マンノース型タンパク質の製造
Document Type and Number:
Japanese Patent JP2010525806
Kind Code:
A
Abstract:
A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Inventors:
Chartier, Joseph
Baum, Gideon
Bert feld, daniel
Shashmueli, Sharon
Lukowitz, Ayala
Baum, Gideon
Bert feld, daniel
Shashmueli, Sharon
Lukowitz, Ayala
Application Number:
JP2010505007A
Publication Date:
July 29, 2010
Filing Date:
April 30, 2008
Export Citation:
Assignee:
Protalix Limited
International Classes:
C12N15/09; A61K38/00; A61K38/46; A61P1/16; A61P7/00; A61P7/04; A61P7/06; A61P11/00; A61P19/08; A61P43/00; C12M1/00; C12N5/10; C12N9/24; C12N9/40; C12N15/82; C12P21/00; C12N
Domestic Patent References:
| JP2006524506A | 2006-11-02 |
Foreign References:
| WO2006040764A2 | 2006-04-20 | |||
| WO2007010533A2 | 2007-01-25 |
Attorney, Agent or Firm:
Nobuaki Kazehaya
Noriko Asano
Noriko Asano