Title:
MANUFACTURE OF PENICILLIN AND CEPHALOSPORINS
Document Type and Number:
Japanese Patent JPS60142993
Kind Code:
A
Abstract:
A process for producing unnatural penicillins and cephalosporin derivatives thereof in which peptide analogs of ACV in which the L- alpha -aminodipyl moiety is replaced by L-S-carboxymethyl cysteine or other substituents, are reacted with cyclase, epimerase and ring expansion enzyme isolated from a cell free extract of a prokaryotic organism such as S. clavuligerus. The product depends upon the presence or absence of co-factors such as ferrous ion, alpha -ketoglutarate, and ascorbate. In an alternative embodiment, a penicillin analog having the formula may be reacted with L-cysteine to produce an analog of isopenicillin N which may be reacted with the enzyme reagent to produce the desired penicillin or cephalosporin.
Inventors:
SOORU URUFU
DONARUDO UESUTOREIKU
SUUZAN JIENSEN
DONARUDO UESUTOREIKU
SUUZAN JIENSEN
Application Number:
JP24635784A
Publication Date:
July 29, 1985
Filing Date:
November 22, 1984
Export Citation:
Assignee:
UNIV KINGSTON
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D499/06; C07D499/58; C07D501/08; C07F9/6561; C07D501/22; C07K1/113; C07K5/06; C07K5/078; C07K5/08; C12N9/00; C12P35/00; C12P35/06; C12P37/00; A61K38/00; C12N11/18; (IPC1-7): A61K31/545; C07D499/58; C07D501/22; C07F9/65; C07K5/06; C07K5/08; C12P35/00; C12P37/00
Attorney, Agent or Firm:
Aoki Akira