Title:
MANUFACTURE OF PIPERAZINE DERIVATIVE
Document Type and Number:
Japanese Patent JPS5976067
Kind Code:
A
Abstract:
Compounds of the formula A-CH-CmH2m-NN-R ¦ R6 wherein R is phenyl; phenyl having one or more substituents attached thereto, said substituents being selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, halogen and trifluoromethyl; a bicyclic aromatic or cycloaliphatic-aromatic ring, especially naphthyl, tetrahydronaphthyl or indanyl; or a mono- or bicyclic heterocyclic ring, especially pyridyl, pyrimidyl, isoquinolyl or thiazolyl; R1is (CH2)pR4 ANGLE ANGLE -N(CH2)n or Q=CR5 ANGLE ¦¦ B -NN-R3 ANGLE C PARALLEL O where B is O OO PARALLEL ANGLE -C- or -S-, n is 2, 3 or 4, R3 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 1 to 4 carbon atoms, R4 and R5, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms, P IS 0 OR 1, AND Q is oxygen or two hydrogens, R2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen, A is a single carbon-to-carbon bond or -OCH2-, R6 is hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms or alkanoyloxy of 1 to 4 carbon atoms, and M IS 0, 1, 2, 3, 4 OR 5, BUT OTHER THAN 0 WHEN R6 is hydroxyl, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THEIR SALTS ARE USEFUL AS CNS-depressants, adrenolytics, antiphologistics, analgesics, antihistamines and anticholesterols.
Inventors:
ERUNSHIYUTO OTSUTOO RENTO
ANTON MENTORUPU
KURUTO SHIYUROMU
PETERU DANNENBERUKU
ANTON MENTORUPU
KURUTO SHIYUROMU
PETERU DANNENBERUKU
Application Number:
JP12926283A
Publication Date:
April 28, 1984
Filing Date:
July 15, 1983
Export Citation:
Assignee:
BOEHRINGER SOHN INGELHEIM
International Classes:
C07D233/72; A61K31/415; A61K31/4166; A61K31/495; A61K31/505; A61K33/44; A61P3/06; A61P9/02; A61P9/12; A61P11/00; A61P11/08; A61P25/00; A61P25/02; A61P25/04; A61P25/20; A61P29/00; A61P43/00; C07D207/27; C07D211/76; C07D239/10; C07D275/02; C07D279/02; C07D295/092; C07D295/135; C07D401/12; C07D403/12; C07D417/12; C07D207/26; (IPC1-7): A61K31/415; A61K31/495; A61K31/505; C07D233/72; C07D401/12; C07D403/12; C07D417/12
Attorney, Agent or Firm:
Hideto Asamura
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