Title:
ポリケチド、及び他の天然物の製造
Document Type and Number:
Japanese Patent JP4751899
Kind Code:
B2
Abstract:
The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
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Inventors:
Alan Mathieu Gregory
Sabine Guy cell
Fulvoje Petcovic
Stephen Moss
Sabine Guy cell
Fulvoje Petcovic
Stephen Moss
Application Number:
JP2008028177A
Publication Date:
August 17, 2011
Filing Date:
February 07, 2008
Export Citation:
Assignee:
Bio Chica Technology Limited
International Classes:
C12N15/09; A61K31/407; A61K31/436; A61K31/706; A61P31/10; A61P35/00; A61P37/04; C07D493/18; C07D498/18; C07H15/04; C07K14/36; C12N1/21; C12N15/10; C12N15/52; C12N15/70; C12N15/76; C12P17/18; C12P19/62; C12P21/02; C12R1/55
Domestic Patent References:
| JP2005532809A | ||||
| JP2008200039A |
Other References:
CHUNG LOLETA,JOURNAL OF ANTIBIOTICS,日本,2001年 3月,V54 N3,P250-256
Journal of Bacteriology,1998年 2月,vol.180,p.809-814
Journal of Bacteriology,1998年 2月,vol.180,p.809-814
Attorney, Agent or Firm:
Toru Ishikawa