Title:
プロスタミドの製造
Document Type and Number:
Japanese Patent JP2005519115
Kind Code:
A
Abstract:
The present invention provides a process for the preparation of a prostamide which comprises the steps of (d) reacting first intermediate having the general formula (I) with DIBAL wherein Z is a protecting group and the dotted line represents the presence or absence of a double bond to yield a second intermediate having the general Formula (II) (b) reacting said second intermediate with Na(TMS)2N and (C6H5)3P<+>(CH2)6CONR2X wherein R is a C1-5 alkyl or hydrogen and X is an anion to yield a third intermediate having the general formula (III) (c) reacting said third intermediate with a protecting agent to yield a fourth intermediate having the general formula IV (e) reacting said fourth intermediate to remove said protecting groups and yield a prostamide having the general formula V
Inventors:
Michael E. Gurst
Jan Audenes
Kasima Gregory Unchuck
Richard Donald Mortimer
E-Hun Le
Brian George Hockfellner
Edward Armand Arsenold
Wen-Run Ye
Jan Audenes
Kasima Gregory Unchuck
Richard Donald Mortimer
E-Hun Le
Brian George Hockfellner
Edward Armand Arsenold
Wen-Run Ye
Application Number:
JP2003572951A
Publication Date:
June 30, 2005
Filing Date:
February 28, 2003
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
International Classes:
C07C405/00; (IPC1-7): C07C405/00
Domestic Patent References:
| JPS52148044A | 1977-12-08 | |||
| JPS6072859A | 1985-04-24 | |||
| JPS545954A | 1979-01-17 | |||
| JPH11255740A | 1999-09-21 |
Foreign References:
| WO2001055101A2 | 2001-08-02 |
Attorney, Agent or Firm:
Aoyama Aoi
Yasuo Shibata
Hiromitsu Takayama
Yasuo Shibata
Hiromitsu Takayama