Title:
MANUFACTURE OF SEPARATING AGENT
Document Type and Number:
Japanese Patent JP3446274
Kind Code:
B2
Abstract:
PURPOSE: To provide a separating agent especially suitable for liquid-phase chromatography by adding methacryloyl isocyanate, etc., to a carrier having an active hydrogen group on the surface and then copolymerizing the carrier with a polymerizable vinyl monomer.
CONSTITUTION: A carrier made of silica gel, polystyrene, etc., having an active hydrogen group e.g. hydroxyl group, carboxyl group, etc., on the surface is used as a carrier for liquid-phase chromatography. Addition reaction of the carrier with a compound, e.g. methacryloyl isocyanate having the formula I or the formula II (R1 is hydrogen or methyl group; n is 1-2 integer) is carried out. Further, the resulting addition reaction product is copolymerized with a copolymerizable vinyl monomer e.g. acrylic acid, acrylamide, etc. Consequently, a polymer part can be introduced into the surface of the carrier and thus a separating agent by which pressure loss is kept from changing and which is suitable for liquid-phase chromatography is provided.
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Inventors:
Hideaki Koba
Tadashi Adachi
Tadashi Adachi
Application Number:
JP32224793A
Publication Date:
September 16, 2003
Filing Date:
December 21, 1993
Export Citation:
Assignee:
Mitsubishi Chemical Corporation
International Classes:
B01J20/281; B01J20/26; B01J20/30; C08F2/44; C08F20/52; C08F20/58; C08F251/00; C08F265/00; C08F291/00; C08F292/00; (IPC1-7): B01J20/30; B01J20/26; C08F2/44; C08F251/00; C08F265/00; C08F292/00
Domestic Patent References:
| JP5170845A | ||||
| JP63304002A | ||||
| JP788366A |
Attorney, Agent or Firm:
Koji Hasegawa