Title:
MANUFACTURE OF SUBSTITUTED BENZYL ESTER
Document Type and Number:
Japanese Patent JPS57106643
Kind Code:
A
Abstract:
A process for preparing a benzyl phenyl-acetate of the formula Iwherein R1 is hydroxy, protected hydroxy, hydrogen, C1-C4 alkyl, C1-C4 alkoxy or halo; one of R2 and R3 is hydrogen and the other is phenoxy or C1-C6 alkoxy; which comprises reacting an alkali metal phenylacetate of the formula IIwith a benzyl halide of the formula IIIwherein M is sodium or potassium, and X is chloro or bromo; in an organic solvent which is inert to esterification and in which the phenylacetic acid salt is substantially insoluble. and in the presence of a catalytic amount of a phase transfer catalyst of. the formulawherein X' is chloro, bromo, iodo, toluenesulfonate or methanesulfonate; R4 and R5 are independently C1-C16 alkyl, phenyl or benzyl: R6 and R7 are independently C1-C16 alkyl; provided that. when X1 is a group other than iodo, the process is carried out in the presence of from 0.1 to 0.5 mole of an alkali metal iodide per mole of product to be produced.
Inventors:
JIEEMUZU MIHAERU GURIIN
CHIYAARUZU AASAA BIYUNERU
CHIYAARUZU AASAA BIYUNERU
Application Number:
JP17630381A
Publication Date:
July 02, 1982
Filing Date:
November 02, 1981
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
C07C69/007; B01J31/00; C07B61/00; C07C67/11; C07C69/732; C07D309/12; C07D498/04; C07D501/06; C07D505/00; (IPC1-7): B01J31/02; C07C67/10; C07C69/007
Previous Patent: JPS57106642
Next Patent: FARNESENCE DERIVATIVE, MUCOSA STABILIZER COMPRISING IT AS ACTIVE INGREDIENT, AND ITS PREPARATION
Next Patent: FARNESENCE DERIVATIVE, MUCOSA STABILIZER COMPRISING IT AS ACTIVE INGREDIENT, AND ITS PREPARATION