To provide a manufacturing method of an adsorbent excellent in strength and solvent resistance, the adsorbent manufactured thereby and an adsorption device excellent in durability.

The manufacturing method of the adsorbent which selectively adsorbs a target compound has a substitution process for bringing a base material, which is mainly constituted of apatite represented by a compositional formula: Ca10(PO4)6[(OH)1-aXa]2 (wherein X is at least one of halogen atoms and a is 0≤a≤1) at least in the vicinity of its surface, into contact with a solution containing ions of at least one kind of divalent metal elements to substitute at least a part of Ca possessed by apatite with the divalent metal element and a baking process for baking the base material after the substitution with the divalent metal element at a temperature from 950°C to the pyrolytic temperature of apatite.