MANUFACTURING METHOD OF DIFLUOROMETHYL SUBSTITUTED COMPOUND

Japanese Patent JP2019156773

A

To provide a method for easily manufacturing a difluoromethyl substituted compound using inexpensive agents.SOLUTION: There is provided a manufacturing method of a difluoromethyl substituted compound using difluoro iodomethane and a catalyst, in which (I) the catalyst is a nickel compound and a nitrogen-containing bidentate ligand, a raw material a compound represented by Ar-Z, wherein Ar is substituted or unsubstituted C6 to 14 aryl group, or substituted or unsubstituted 5 to 10-membered heteroaryl group, Z represents a group represented by B(OR)or a group represented by MgX, the difluoromethyl substituted compound is a compound represented by Ar-CFH, or (II) the catalyst is a palladium compound and a diphosphine ligand, the raw material is a compound represented by Q-B(OR), wherein Q represents a substituted or unsubstituted C6 to 10 aryl group, a substituted or unsubstituted 5 to 10-membered heteroaryl group, or a group represented by Ar-CH=CH-, Rrepresents a hydrogen atom or a C1 to 6 alkyl group, or a compound represented by Q-Zn-Q, and the difluoromethyl substituted compound is a compound represented by Q-CFH.SELECTED DRAWING: None

MIKAMI KOICHI
MOTOHASHI TAKUKI
SAITO DAICHI
HORI KAISHI

JP2018046549A

September 19, 2019

March 14, 2018

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TOKYO INST TECH
NIPPON SODA CO

C07C17/26; B01J31/18; B01J31/24; C07C22/08; C07C41/30; C07C43/225; C07C45/68; C07C47/55; C07C67/343; C07C69/76; C07C201/12; C07C205/11; C07C253/30; C07C255/50; C07C319/20; C07C323/09; C07D209/08; C07D215/12; C07D307/79; C07D307/91; C07D317/52; C07F7/12

Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita

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