Title:
MANUFACTURING METHOD OF OPTICALLY ACTIVE AMINONITRILE COMPOUND AND MANUFACTURING METHOD OF OPTICALLY ACTIVE AMINO ACID
Document Type and Number:
Japanese Patent JP2017145214
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for manufacturing an optically active aminonitrile compound with high purity suitable for manufacturing optically active amino acid and a method for manufacturing an optically active amino acid.SOLUTION: An optically active imine compound is obtained by condensing an optically active primary amine compound and a carbonyl compound in a solvent, a crystal of an optically active aminonitrile compound is deposited by adding hydrogen cyanide or a salt thereof to the imine compound in a solvent and asymmetric amplification for extremely enhancing diastereomer ratio thereof is conducted. The resulting aminonitrile compound with high optical purity is converted to optically active amino acid by known acid hydrolysis without deteriorating optical purity.SELECTED DRAWING: Figure 1
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Inventors:
KAWASAKI TSUNEO
TOKUNAGA YUJI
TAKAMATSU NAOYA
TOKUNAGA YUJI
TAKAMATSU NAOYA
Application Number:
JP2016028189A
Publication Date:
August 24, 2017
Filing Date:
February 17, 2016
Export Citation:
Assignee:
UNIV FUKUI
International Classes:
C07C253/08; C07C227/26; C07C227/34; C07C229/36; C07C253/34; C07C255/42; C07D307/54
Attorney, Agent or Firm:
Toshikazu Fukai
Yosuke Tsushima
Waseda Shigeyuki
Yosuke Tsushima
Waseda Shigeyuki