Title:
キヌクリジン類の製造法
Document Type and Number:
Japanese Patent JP5452165
Kind Code:
B2
Abstract:
Provided is a production method for a cis-QMF, which has a low environmental burden and is industrially advantageous. Specifically provided is a production method for a cis-type 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine hydrochloride, including: reacting a cis-trans isomer mixture of 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine with p-nitrobenzoic acid; resolving the resultant product to produce a cis-type 2-alkylspiro(1,3-oxathiolane-5,3′)quinuclidine p-nitrobenzoate; and converting the p-nitrobenzoate into a hydrochloride.
Inventors:
Fujio Seio
Mitabiko Komiko
Yutaka Kitagawa
Mitabiko Komiko
Yutaka Kitagawa
Application Number:
JP2009243947A
Publication Date:
March 26, 2014
Filing Date:
October 23, 2009
Export Citation:
Assignee:
Daiichi Fine Chemical Co., Ltd.
Daiichi Sankyo Co., Ltd.
Daiichi Sankyo Co., Ltd.
International Classes:
C07D497/20; C07B57/00; C07C205/57
Domestic Patent References:
| JP8319287A | ||||
| JP61280497A | ||||
| JP6445387A | ||||
| JP6416787A | ||||
| JP1104079A |
Foreign References:
| US20080249312 | ||||
| US20090182146 |
Other References:
IL 81652 A1,1991年 5月12日
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto