Title:
無菌ポリヌクレオチド系薬剤の製造方法
Document Type and Number:
Japanese Patent JP5390059
Kind Code:
B2
Abstract:
The present invention relates to a novel method for producing formulations comprising a polynucleotide, block copolymer and cationic surfactant. The formulations produced by the current method are suitable for use in polynucleotide based medicaments. A suitable method of production disclosed herein additionally comprises cold filtering a mixture of a polynucleotide, block copolymer and cationic surfactant, thereby sterilizing the formulation. The method of the present invention also eliminates the need for thermal cycling of the formulation, thereby reducing the time and expense required to produce large quantities of a formulation during commercial manufacturing. The present invention also relates to novel cationic lipids.
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Inventors:
Gale, Andrew
Enus, Joel
Enus, Joel
Application Number:
JP2004565151A
Publication Date:
January 15, 2014
Filing Date:
December 02, 2003
Export Citation:
Assignee:
Baikal Incorporated
International Classes:
A61K48/00; A61K9/00; A61K9/107; A61K47/18; A61K47/34; C07C211/63; C07C217/28; C07C219/06; C07C219/14
Other References:
特許第2538474号公報
国際公開第02/00844号
米国特許第5811088号明細書
国際公開第2002/052002号
特表2002-536399号公報
特表2001-508815号公報
国際公開第99/61032号公報
特表平11-508231号公報
国際公開第02/00844号
米国特許第5811088号明細書
国際公開第2002/052002号
特表2002-536399号公報
特表2001-508815号公報
国際公開第99/61032号公報
特表平11-508231号公報
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei