MARKER AND APPLICATION OF CALCIUM OVERLOAD-MEDIATED NEURONAL DEATH

Title:

MARKER AND APPLICATION OF CALCIUM OVERLOAD-MEDIATED NEURONAL DEATH

Document Type and Number:

Japanese Patent JP2023152619

Kind Code:

A

Abstract:

To provide markers and applications of calcium overload-mediated neuronal death.SOLUTION: In one aspect, provided is an application of a marker of calcium overload-mediated neuronal death in the therapeutic drug preparation and disease detection method for age-related neurodegenerative diseases, in which the marker is hyperphosphorylated TLK2 and further comprises a TLK2 inhibitor drug, a TLK2 RNA interference factor, a TLK2 knockout factor, or an RNA interference factor with TLK2 knocked out.SELECTED DRAWING: Figure 1

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Inventors:

LIU LEI
GONG FANGYAN

Application Number:

JP2022174533A

Publication Date:

October 17, 2023

Filing Date:

October 31, 2022

Export Citation:

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Assignee:

CAPITAL MEDICAL UNIV

International Classes:

C12Q1/48; A61K31/454; A61K31/5415; A61K31/7088; A61K31/7105; A61K45/00; A61K48/00; A61P21/02; A61P25/16; A61P25/28; A61P27/06; C12N15/113

Attorney, Agent or Firm:

Patent Attorney Corporation Cosmos International Patent and Trademark Office

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