Title:
Ｃ型肝炎の治療効果を予測するためのマーカー及びＣ型肝炎の治療効果の予測を行う方法並びにＣ型肝炎の予防又は治療剤
Document Type and Number:
Japanese Patent JP5727694
Kind Code:
B2
Abstract:
Disclosed are a marker for higher accuracy prediction of therapeutic effect, and a higher accuracy prediction method for the therapeutic effect on hepatitis C using the marker in a peg-IFN/RBV combination therapy. Specifically disclosed are a marker for predicting the therapeutic effect on hepatitis C that is characterized by being an oligonucleotide or a polynucleotide present in the human genome and by comprising one or more types selected from among the genetic polymorphism indicated below or those in a state of linkage disequilibrium (R2>0.8) with the same, and a prediction method for the therapeutic effect on hepatitis C using the marker. The genetic polymorphism present within a polynucleotide represented by rs12043519, rs1986953, rs13392065, rs16987149, rs16987155, rs2374341, rs2374342, rs7566701, rs12713624, rs10208788, rs10208883, rs9876122, rs2036081, rs13122167, rs4488950, rs13150115, rs7663113, rs1379606, rs913500, rs6458003, rs6906840, rs2224068, rs9390164, rs4512312, rs757844, rs4876271, rs7942675, rs17787293, rs917334, rs6489019, rs6489020, rs6489021, rs11610391, rs9528038, rs341554, rs2325219, rs1353348, rs2076954, rs12907066, rs8075713, rs4795794, rs955155, rs12972991, rs12980275, rs8105790, rs11881222, rs8103142, rs28416813, rs4803219, rs8099917, rs7248668, rs10853728, rs4803223, rs12980602, rs4803224, and sequence 59.
More Like This:
Inventors:
Yasuto Tanaka
Masashi Mizogami
Katsushi Tokunaga
Masashi Mizogami
Katsushi Tokunaga
Application Number:
JP2009192615A
Publication Date:
June 03, 2015
Filing Date:
August 21, 2009
Export Citation:
Assignee:
Human Science Foundation
Public University Corporation Nagoya City University
Public University Corporation Nagoya City University
International Classes:
C12N15/09; C12Q1/68
Other References:
dbSNP [online],rs#: rs11881222,,2004年 2月19日
dbSNP [online],rs#: rs8105790,,2003年 7月 4日
dbSNP [online],rs#: rs4803219,,2003年 2月12日
dbSNP [online],rs#: rs7248668,,2003年 6月30日
GE D. et al.,Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance,Nature,2009年 8月16日,Vol.461, No.7262,pp.399-401
SELZNER N. and MCGILVRAY I.,Can genetic variations predict HCV treatment outcomes?,J. Hepatol.,2008年 7月21日,Vol.49, No.4,pp.494-497
MORGAN T. R. et al.,DNA polymorphisms and response to treatment in patients with chronic hepatitis C: results from the HALT-C trial,J. Hepatol.,2008年 5月 5日,Vol.49, No.4,pp.548-556
dbSNP [online],rs#: rs8105790,
dbSNP [online],rs#: rs4803219,
dbSNP [online],rs#: rs7248668,
GE D. et al.,Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance,Nature,2009年 8月16日,Vol.461, No.7262,pp.399-401
SELZNER N. and MCGILVRAY I.,Can genetic variations predict HCV treatment outcomes?,J. Hepatol.,2008年 7月21日,Vol.49, No.4,pp.494-497
MORGAN T. R. et al.,DNA polymorphisms and response to treatment in patients with chronic hepatitis C: results from the HALT-C trial,J. Hepatol.,2008年 5月 5日,Vol.49, No.4,pp.548-556
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga
Yuriko Shinobu
Takuya Osugi
Aki Soga