Title:
ガンマ-セクレターゼ阻害剤としてのマロンアミド誘導体
Document Type and Number:
Japanese Patent JP4662914
Kind Code:
B2
Abstract:
The invention relates to malonamide derivatives of formula wherein each of the variables are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The compounds are gamma-secretase inhibitors. Thus, the invention also relates to pharmaceutical compositions containing these compounds and to a method of treating Alzheimer's disease by administering the compounds of the invention.
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Inventors:
Flounder, Gweed
Gogley, annick
Jacobsen, Helmut
Kitas, Eric Argylios
Peters, Yens-Uwe
Gogley, annick
Jacobsen, Helmut
Kitas, Eric Argylios
Peters, Yens-Uwe
Application Number:
JP2006500017A
Publication Date:
March 30, 2011
Filing Date:
January 27, 2004
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D243/24; A61K31/472; A61K31/4725; A61K31/55; A61K31/551; A61K31/5513; A61P25/28; C07C237/08; C07C237/12; C07C237/14; C07C237/22; C07D209/14; C07D209/18; C07D209/44; C07D211/70; C07D215/227; C07D215/38; C07D217/06; C07D223/18; C07D243/12; C07D243/14; C07D243/26; C07D265/30; C07D295/18; C07D401/04; C07D401/06; C07D401/12; C07D403/06; C07D405/12; C07D409/06; C07D409/12; C07D453/06; C07D471/04; C07D471/06; C07D471/08; C07D487/06; C07D491/056; C07D215/22
Other References:
Tetrahedron letters,2001年,42,4479-4482頁
Parasitology,1990年,100,201-207頁
Parasitology,1990年,100,201-207頁
Attorney, Agent or Firm:
Hajime Tsukuni
Yoko Tanaka
Fumio Shinoda
Yoko Tanaka
Fumio Shinoda