Title:
Material and a method relevant to cardiovascular imaging
Document Type and Number:
Japanese Patent JP6018585
Kind Code:
B2
Abstract:
The invention provides conjugates for imaging plaques, such as cardiovascular plaques, as well as associated pharmaceutical compositions. Other aspects of the invention include methods for administering and imaging such conjugates and compositions, and using the imaging to characterise plaques. The conjugates of the invention distinguish between tropoelastin and elastin in plaques. The presence of tropoelastin can act as an indication that a plaque is liable to rupture or erode. Such information allows assessment of disease progression and response to treatment.
Inventors:
Bottonal, Rene
Finikaridou, Alkistis
Finikaridou, Alkistis
Application Number:
JP2013553019A
Publication Date:
November 02, 2016
Filing Date:
February 08, 2012
Export Citation:
Assignee:
King's College London
International Classes:
A61K49/00
Domestic Patent References:
| JP2008509921A | ||||
| JP2002520421A | ||||
| JP63503062A | ||||
| JP3505094A | ||||
| JP5507276A | ||||
| JP1501796A |
Foreign References:
| WO2010079156A1 | ||||
| WO2009063995A1 | ||||
| WO2011005322A2 |
Other References:
Arterioscler. Thromb. Vasc. Biol.,2003年,Vol.23, No.4,p.582-587
J. Vasc. Surg.,2001年,Vol.33, No.3,p.614-620
Circ. J.,2009年,Vol.73, No.11,p.2154-2162
J. Vasc. Surg.,2001年,Vol.33, No.3,p.614-620
Circ. J.,2009年,Vol.73, No.11,p.2154-2162
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Reiko Izumiya
Takeda Takeshi
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Reiko Izumiya
Takeda Takeshi
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