MATRIX METALLOPROTEINASE INHIBITOR AND PYRIDYL AZOBENZENE DERIVATIVE USED THEREFOR

Title:

MATRIX METALLOPROTEINASE INHIBITOR AND PYRIDYL AZOBENZENE DERIVATIVE USED THEREFOR

Document Type and Number:

Japanese Patent JP2011032210

Kind Code:

A

Abstract:

To provide an MMP (matrix metalloproteinase) inhibitor reduced in side effects, that has no hydroxamic acid active moiety and can selectively inhibit a zinc ion as an active center.

The MMP inhibitor includes, as an active ingredient, an azobenzene derivative having a structure represented by formula 1, 2, and 3 wherein R1 represents halogen, hydroxyl, methyl, methoxy or carboxyl, R2 to R4 each independently represents hydrogen, halogen, hydroxyl or 1-8C alkyl or alkoxy (including those groups which are branched at any position). The compound represented by formulae 1, 2, and 3 is newly synthesized.

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Inventors:

TANAKA NAOKI
EMI KAZUYA
OE SATORU
FUKUMORI MASAHIRO
EMOTO SHOKO
ZAMAMI YOSHIHITO
TSUBOI SEIJI
OTSUKA CHIE
SASAKI KENJI

Application Number:

JP2009179931A

Publication Date:

February 17, 2011

Filing Date:

July 31, 2009

Export Citation:

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Assignee:

SHIPRO KASEI KAISHA LTD

International Classes:

A61K31/655; A61P35/00; A61P35/04; A61P43/00; C07D213/76; C07C245/08

Foreign References:

CA1155856A

1983-10-25

Attorney, Agent or Firm:

Shinji Nakagawa

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