Title:
経皮的投与のためのマトリックスパッチ
Document Type and Number:
Japanese Patent JP4511691
Kind Code:
B2
Abstract:
A composition and method for enhancing transdermal penetration of a basic drug are described. The composition comprises a matrix patch comprising an effective amount of a basic drug, preferably having a pKa of about 8.0 or greater, an effective amount of penetration enhancer consisting essentially of triacetin, and a polymer later preferably comprising a pressure-sensitive adhesive. A preferred basic drug is oxybutynin and acid addition salts thereof. The method for enhancing transdermal penetration comprises applying the matrix patch to a selected area of skin.
Inventors:
Quang, Dan Yi
Desh Panday, Nina Doe
Venkateshwaran, Srinivasan
Charles Dee, Evert
Desh Panday, Nina Doe
Venkateshwaran, Srinivasan
Charles Dee, Evert
Application Number:
JP2000201747A
Publication Date:
July 28, 2010
Filing Date:
July 04, 2000
Export Citation:
Assignee:
Watson Laboratories, Inc.
International Classes:
A61K9/70; A61K9/00; A61K31/137; A61K31/138; A61K31/167; A61K31/216; A61K31/404; A61K31/4458; A61K31/46; A61K31/485; A61K31/5415; A61K31/55; A61K47/10; A61K47/14; A61K47/30; A61K47/32; A61P9/00; A61P9/06; A61P21/02; A61P23/02; A61P25/04; A61P25/24; A61P25/26; A61P27/02
Domestic Patent References:
| JP3228341B2 | ||||
| JP6145052A | ||||
| JP6399008A | ||||
| JP63126832A | ||||
| JP5148141A |
Foreign References:
| US4814173 |
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Go Kajita
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Go Kajita