Title:
HLAという背景において提示されたペプチドに特異的なCD8+Tリンパ球個体群の検出及び精製手段
Document Type and Number:
Japanese Patent JP5020452
Kind Code:
B2
Abstract:
The invention concerns multimers developed from recombinant proteins analogues of MHC class I, characterised in that the proteins comprise at least an alteration in the zone of interaction of a heavy chain with the T-cell co-receptor CD8 leading to a reduction, even the suppression of the affinity of the interaction between the heavy chain and CD8. Said multimers forming complexes with antigenic peptides are useful for diagnostic and therapeutic purposes.
Inventors:
Lan francois
Bodynie marie
Davodot Francois
Bonneville Marc
Bodynie marie
Davodot Francois
Bonneville Marc
Application Number:
JP2001522275A
Publication Date:
September 05, 2012
Filing Date:
September 05, 2000
Export Citation:
Assignee:
An institute Nacional de la saint et de la l'ercheche medical
International Classes:
C12N15/09; G01N33/53; A61K35/14; A61K35/24; A61P37/02; A61P37/04; C07K14/74; C12N5/0783; C12Q1/02; G01N33/569; A61K35/12; A61K38/00
Foreign References:
| US5635363A | 1997-06-03 |
Attorney, Agent or Firm:
Norihiko Hibi
Einosuke Kishimoto
Akira Watanabe
Einosuke Kishimoto
Akira Watanabe