Title:
UGT1A1に基づいたがんの改善治療の手段及び方法
Document Type and Number:
Japanese Patent JP2005505526
Kind Code:
A
Abstract:
The present invention relates to the use of irinotecan or derivative thereof for the preparation of a pharmaceutical composition for treating cancer, especially, colorectal cancer, cervical cancer, gastric cancer, lung cancer, malignant glioma, ovarian cancer, and pancreatic cancer in a patient having a genotype with a variant allele which comprises a polynucleotide in accordance with the present invention. Preferably, a nucleotide deletion, addition and/or substitution comprised by said polynucleotide results in an altered expression of a variant allele compared to the corresponding wild type allele or an altered activity of the polypeptide encoded by the variant allele compared to the polypeptide encoded by the corresponding wild type allele. Finally, the present invention relates to a method for selecting a suitable therapy for a subject suffering from colorectal cancer, cervical cancer, gastric cancer, lung cancer, malignant glioma, ovarian cancer, and pancreatic cancer.
Inventors:
Heinrich, Gunter
Cherub, rainhold
Cherub, rainhold
Application Number:
JP2003518545A
Publication Date:
February 24, 2005
Filing Date:
July 23, 2002
Export Citation:
Assignee:
Epidaurus Biotechnology Akchen Gesell Shaft
International Classes:
C12N15/09; A61K31/235; A61K31/277; A61K31/341; A61K31/343; A61K31/352; A61K31/353; A61K31/409; A61K31/4152; A61K31/4709; A61K31/4741; A61K31/4745; A61K31/49; A61K31/496; A61K31/519; A61K31/565; A61K31/566; A61K31/575; A61K38/00; A61K45/00; A61P1/00; A61P1/18; A61P11/00; A61P15/00; A61P25/00; A61P35/00; A61P43/00; C07D491/052; C07D491/22; C12Q1/68; (IPC1-7): A61K31/4745; A61K31/235; A61K31/352; A61K31/353; A61K31/409; A61K31/565; A61K31/566; A61K45/00; A61P35/00
Other References:
JPN5003022686, ＩＮＮＯＣＥＮＴＩ Ｆ ｅｔａｌ．, ＤＲＵＧ ＭＥＴＡＢＯＬＩＳＭ ＡＮＤ ＤＩＳＰＯＳＩＴＩＯＮ, 200104, Ｖｏｌ．２９， Ｎｏ．４， ＰＡＲＴ２, ｐｐ．５９６−６００, US, ＷＩＬＬＩＡＭＳ ＡＮＤ ＷＩＬＫＩＮＳ．
JPN5003022687, ＡＮＤＯ Ｙ ｅｔ ａｌ．, ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ, 20001215, Ｖｏｌ．６０, ｐｐ．６９２１−６９２６, US, ＡＭＥＲＩＣＡＮ ＡＳＳＯＣＩＡＴＩＯＮ ＦＯＲ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ
JPN5003022688, ＩＹＥＲ Ｌ ｅｔ ａｌ, ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＩＮＶＥＳＴＩＧＡＴＩＯＮ, 19980215, Ｖｏｌ．１０１， Ｎｏ．４, ｐｐ．８４７−８５４, US
JPN7009004733, ＡＮＮＡＬＳ ＯＦ ＯＮＣＯＬＯＧＹ, 199710, Ｖｏｌ．８， Ｎｏ．１０, ｐｐ．１０４９−１０５１
JPN5003022687, ＡＮＤＯ Ｙ ｅｔ ａｌ．, ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ, 20001215, Ｖｏｌ．６０, ｐｐ．６９２１−６９２６, US, ＡＭＥＲＩＣＡＮ ＡＳＳＯＣＩＡＴＩＯＮ ＦＯＲ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ
JPN5003022688, ＩＹＥＲ Ｌ ｅｔ ａｌ, ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＩＮＶＥＳＴＩＧＡＴＩＯＮ, 19980215, Ｖｏｌ．１０１， Ｎｏ．４, ｐｐ．８４７−８５４, US
JPN7009004733, ＡＮＮＡＬＳ ＯＦ ＯＮＣＯＬＯＧＹ, 199710, Ｖｏｌ．８， Ｎｏ．１０, ｐｐ．１０４９−１０５１
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
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