To obtain calculation means for calculating to measure average sublimation surface temperature of a whole material to be dried and water vapor moving resistance in a dried layer with use of data collected by measuring vacuum degree variation in a drying chamber by use of a vacuum meter, without neither measuring and monitoring product temperature of the material to be dried by inserting a product temperature sensor of an individual vessel nor increasing the pressure, which causes occurrence of collapse, in the drying chamber, in the period of primary drying when the material to be dried is charged into a drying chamber in a freeze-drying apparatus and freeze-dried.
An opening controller C with an angle sensor controlling the opening of a main pipe a is equipped in the main pipe a of the freeze-drying apparatus. A relational expression among sublimation load Qm, opening angle θ of the opening controller C, and main pipe resistance R(θ) is sought in advance. The opening controller C is rotated in the direction to open the opening with a constant time interval in the period of primary drying, to measure data of opening angle θ of the opening controller C before and after the rotation, vacuum degree Pdc in the drying chamber, and vacuum degree Pct in the cold trap CT. Average sublimation temperature of the material to be dried is measured by calculation from the measured data and the relational expression.
| WO/2008/042408 | LYOPHILIZATION METHODS AND APPARATUSES |
| JP3229081 | Chamber for freeze-drying machine |
| JPH0618208 | [Name of invention] Vacuum freeze-drying device |
TONEGAWA KAZUNORI
HOSOMI HIROSHI
SAMA RYOJI
| JP2008128585A | 2008-06-05 | |||
| JP2010266086A | 2010-11-25 |
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