Title:
MECHANISM-BASED TARGETED PANCREATIC β CELL IMAGING AND THERAPY
Document Type and Number:
Japanese Patent JP2015078223
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a composition useful in all diagnosis, prognosis and therapy to pancreatic diseases in mammals.SOLUTION: The invention provides a composition comprising an anti-diabetic agent, a chelating agent, and a chelated metal ion. A disease of pancreas is diabetes, an anti-diabetic agent is nateglinide, glipizide, glyburide or glimepiride, and a metal ion is β emitter, a chelating agent is diethylenetriamine pentaacetic acid (DTPA), and the chelated metal ion isRe,Y, orHo.
Inventors:
YANG DAVID J
OH CHANG-SOK
KOHANIM SAADY
YU DONG-FANG
AZHDARINIA ALI
BRYANT JERRY
OH CHANG-SOK
KOHANIM SAADY
YU DONG-FANG
AZHDARINIA ALI
BRYANT JERRY
Application Number:
JP2014254707A
Publication Date:
April 23, 2015
Filing Date:
December 17, 2014
Export Citation:
Assignee:
UNIV TEXAS
International Classes:
A61K47/48; A61K31/175; A61K31/198; A61K31/426; A61K31/4439; A61K31/64; A61K45/00; A61K47/16; A61K49/00; A61K51/00; A61K51/04; A61P1/18; A61P3/10
Domestic Patent References:
| JPH02184698A | 1990-07-19 | |||
| JPH1095737A | 1998-04-14 |
Foreign References:
| WO2001044177A2 | 2001-06-21 |
Other References:
JPN6010042739; メルクマニュアル 日本語版 第１７版, 19991210, ｐｐ．１６７-１７９
JPN6015048228; Ａｎｎ Ｎｕｃｌ Ｍｅｄ， ｖｏｌ．２６（３）， （２０１２） ｄｏｉ： １０．１１５５／２０１２／８２８１３９． Ｅｐｕｂ ２０１２ Ｊｕｎ １０．
JPN6010042743; Ｍａｇｉｌｌ-Ｌｅｗｉｓ Ｊ: 'Ｔｈｅ Ｅｘｐｌｏｄｉｎｇ Ｐｒｏｂｌｒｅｍ ｏｆ Ｄｉａｂａｔｅｓ' Ｄｒｕｇ Ｔｏｐｉｃｓ ９巻４９号, 20010507
JPN6010042734; Ｒｏｓｉｅｒｅ Ａ ｅｔ ａｌ．: 'Ｉｎｔｒａｏｐｅｒａｔｉｖｅ ｇａｍｍａ ｐｒｏｂｅ ｄｅｔｅｃｔｉｏｎ ｏｆ ｉｎｓｕｌｉｎｏｍａ ｉｎ ａｎ ｅｌｄｅｒｌｙ ｐａｔｉｅｎｔ ｗｉｔｈ ｐａｎｃｒｅａｔｉｃ ｃｙｓｔｉｃ ｌｅｓｉ' Ｃｌｉｎ Ｅｎｄｏｃｒｉｎｏｌ （Ｏｘｆ） ５７巻４号, 200210, ｐｐ．５４７-５４９
JPN6010042737; Ｃｌｅｍｅｎｓ Ａ ｅｔ ａｌ．: 'Ｏｃｔｒｅｏｔｉｄｅ （ｓｏｍａｔｏｓｔａｔｉｎ ａｎａｌｏｇ） ｔｒｅａｔｍｅｎｔ ｒｅｄｕｃｅｓ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌ ｄｙｓｆｕｎｃｔｉｏｎ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｄｉａ' Ｍｅｔａｂｏｌｉｓｍ． ４８巻１０号, 199910, ｐｐ．１２３６-１２４０
JPN6010042731; Ｈｅｉｎｄｅｌ ＮＤ ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｅｓ ａｎｄ Ｔｉｓｓｕｅ Ｄｉｓｔｒｉｂｕｔｉｏｎ ｏｆ ９９ｍＴｃ-Ｓｕｌｆｏｎｙｌｕｒｅａｓ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ ６４巻４号, 197504, ｐｐ．６８７-６８９
JPN6010042733; Ｓｈｉｌｉｎｇ ＨＵ ｅｔ ａｌ．: 'Ｐａｎｃｒｅａｔｉｃ beta-ｃｅｌｌ ＫＡＴＰ ｃｈａｎｎｅｌ ａｃｔｉｖｉｔｙ ａｎｄ ｍｅｍｂｒａｎｅ-ｂｉｎｄｉｎｇ ｓｔｕｄｉｅｓ ｗｉｔｈ Ｎａｔｅｇｌｉｎｉｄｅ：Ａ Ｃｏｍｐａｒｉｓｏｎ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｙ ａｎｄ Ｅｘｐｅｒｉｍｅｎｔａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ ２９３巻, 2000, ｐｐ．４４４-４５２
JPN6015048228; Ａｎｎ Ｎｕｃｌ Ｍｅｄ， ｖｏｌ．２６（３）， （２０１２） ｄｏｉ： １０．１１５５／２０１２／８２８１３９． Ｅｐｕｂ ２０１２ Ｊｕｎ １０．
JPN6010042743; Ｍａｇｉｌｌ-Ｌｅｗｉｓ Ｊ: 'Ｔｈｅ Ｅｘｐｌｏｄｉｎｇ Ｐｒｏｂｌｒｅｍ ｏｆ Ｄｉａｂａｔｅｓ' Ｄｒｕｇ Ｔｏｐｉｃｓ ９巻４９号, 20010507
JPN6010042734; Ｒｏｓｉｅｒｅ Ａ ｅｔ ａｌ．: 'Ｉｎｔｒａｏｐｅｒａｔｉｖｅ ｇａｍｍａ ｐｒｏｂｅ ｄｅｔｅｃｔｉｏｎ ｏｆ ｉｎｓｕｌｉｎｏｍａ ｉｎ ａｎ ｅｌｄｅｒｌｙ ｐａｔｉｅｎｔ ｗｉｔｈ ｐａｎｃｒｅａｔｉｃ ｃｙｓｔｉｃ ｌｅｓｉ' Ｃｌｉｎ Ｅｎｄｏｃｒｉｎｏｌ （Ｏｘｆ） ５７巻４号, 200210, ｐｐ．５４７-５４９
JPN6010042737; Ｃｌｅｍｅｎｓ Ａ ｅｔ ａｌ．: 'Ｏｃｔｒｅｏｔｉｄｅ （ｓｏｍａｔｏｓｔａｔｉｎ ａｎａｌｏｇ） ｔｒｅａｔｍｅｎｔ ｒｅｄｕｃｅｓ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌ ｄｙｓｆｕｎｃｔｉｏｎ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｄｉａ' Ｍｅｔａｂｏｌｉｓｍ． ４８巻１０号, 199910, ｐｐ．１２３６-１２４０
JPN6010042731; Ｈｅｉｎｄｅｌ ＮＤ ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｅｓ ａｎｄ Ｔｉｓｓｕｅ Ｄｉｓｔｒｉｂｕｔｉｏｎ ｏｆ ９９ｍＴｃ-Ｓｕｌｆｏｎｙｌｕｒｅａｓ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ ６４巻４号, 197504, ｐｐ．６８７-６８９
JPN6010042733; Ｓｈｉｌｉｎｇ ＨＵ ｅｔ ａｌ．: 'Ｐａｎｃｒｅａｔｉｃ beta-ｃｅｌｌ ＫＡＴＰ ｃｈａｎｎｅｌ ａｃｔｉｖｉｔｙ ａｎｄ ｍｅｍｂｒａｎｅ-ｂｉｎｄｉｎｇ ｓｔｕｄｉｅｓ ｗｉｔｈ Ｎａｔｅｇｌｉｎｉｄｅ：Ａ Ｃｏｍｐａｒｉｓｏｎ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｙ ａｎｄ Ｅｘｐｅｒｉｍｅｎｔａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ ２９３巻, 2000, ｐｐ．４４４-４５２
Attorney, Agent or Firm:
Nobuaki Kazehaya
Noriko Asano
Noriko Asano