Title:
内皮細胞の接着および分化を促進するコーティングを有する医療用デバイス
Document Type and Number:
Japanese Patent JP2005523050
Kind Code:
A
Abstract:
Compositions and methods are provided for producing a medical device such as a stent (1.07), a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix (1.06) which incorporates antibodies (1.03), antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen (1.02) to immobilize the cells (1.01) at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting th progenitor endothelial cell (1.01) to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as rest enosis, artherosclerosis or other types of vessel obstructions are disclosed.
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Inventors:
Kutric, Michelle, Jay., Bee.
Cotton, Robert, Jay., Junior.
Roland, Stephen M.
Kriszewski, Michelle, A.
Cotton, Robert, Jay., Junior.
Roland, Stephen M.
Kriszewski, Michelle, A.
Application Number:
JP2003565314A
Publication Date:
August 04, 2005
Filing Date:
February 06, 2003
Export Citation:
Assignee:
ORBUS MEDICAL TECHNOLOGIES Inc.
International Classes:
A61M1/14; A61F2/82; A61K31/721; A61K39/395; A61L17/00; A61L27/00; A61L27/34; A61L27/54; A61L29/00; A61L31/00; A61L31/10; A61L31/16; A61M25/00; A61M29/02; A61B; A61L; (IPC1-7): A61L31/00; A61K39/395; A61L17/00; A61L27/00; A61L29/00; A61M1/14; A61M25/00; A61M29/02
Foreign References:
| WO2001068158A1 | 2001-09-20 | |||
| WO2000032249A1 | 2000-06-08 |
Attorney, Agent or Firm:
Masayoshi Misawa