Title:
１５α，１６α−メチレン基及び飽和１７，１７−スピロラクトン環を有する１９−ノル−ステロイド誘導体、その使用及びこれらの誘導体を含む医薬品
Document Type and Number:
Japanese Patent JP5600071
Kind Code:
B2
Abstract:
The 15α,16α-methylene-17-hydroxy-19-nor-17-pregna-4-en-3-one-21-carboxylic acid γ-lactone derivatives of the present invention possess progestational efficacy. They have the general chemical formula I, in which Z is selected from the group comprising an oxygen atom, two hydrogen atoms, NOR and NNHSO2R, where R is hydrogen, C1-C10-alkyl, aryl or C7-C20-aralkyl, R4 is hydrogen or halogen, and moreover either: R6a, R6b together form methylene or 1,2-ethanediyl or R6a is hydrogen and R6b is selected from the group comprising hydrogen, C1-C10-alkyl, C2-C10-alkenyl or C2-C10-alkynyl, and R7 is selected from the group comprising hydrogen, C1-C10-alkyl, C3-C6-cycloalkyl, C2-C10-alkenyl or C2-C10-alkynyl, or: R6a is hydrogen and R6b and R7, together, denote a bond, an oxygen or form methylene, R18 represents hydrogen or C1-C3-alkyl and in addition include their solvates, hydrates, stereoisomers and salts.
Inventors:
Krall, Ulrich
クーンケ, Joachim
A ball man, Rolf
フーブナー, Jan
A link, スフェン
Frenzel, Thomas
Menges, Frederic
ボルデン, Steffen
The moon, Hans * Peter
Presle, カトヤ
クーンケ, Joachim
A ball man, Rolf
フーブナー, Jan
A link, スフェン
Frenzel, Thomas
Menges, Frederic
ボルデン, Steffen
The moon, Hans * Peter
Presle, カトヤ
Application Number:
JP2010540082A
Publication Date:
October 01, 2014
Filing Date:
December 23, 2008
Export Citation:
Assignee:
Beyer intellectual property gesellschaft mitt ベシュレンクテル ハフツング Bayer Intellectual Property GmbH
International Classes:
C07J53/00; A61K31/565; A61K31/585; A61P5/26; A61P5/34; A61P5/42; A61P15/12; A61P15/18; A61P43/00
Attorney, Agent or Firm:
Aoki 篤
Ishida 敬
Tsumoru Fukumoto
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Tsuda Hidenao
Ishida 敬
Tsumoru Fukumoto
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Tsuda Hidenao