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Title:
置換されたヘテロ環-ノルボルニルアミノ誘導体、その製造法、その医薬品または診断剤としての使用、およびそれを含有する医薬品
Document Type and Number:
Japanese Patent JP2004517967
Kind Code:
A
Abstract:
Substituted heterocyclo-norbornylaminoderivatives having: a) an exo-configuration nitrogen and an endo-fused five-membered ring or six-membered ring of the formula (I) or b) an exo-configuration nitrogen and an exo-fused five-membered ring or six-membered ring of the formula (Ia), wherein Rn, Het, A, B and T have the meanings given in the claims. These compounds have a variety of uses. They can be used as antihypertensives, for the reduction or prevention of is chemically induced damage, as pharmaceuticals for surgical interventions, for the treatment of ischemia of the nervous system, including stroke and cerebral edema, for the treatment of ischemia due to shock and disturbed respiratory drive, for the treatment of snoring, as a laxative, as an agent against ectoparasites, for the prevention of gallstone formation, as an antiatherosclerotic, as an agent against diabetic late complications, cancers, fibrotic disorders, endothelial dysfunction, organ hypertrophy, and organ hyperplasia. The compounds of the invention are inhibitors of the cellular sodium-proton antiporter. Additonally, the compounds of the invention influence the serum lipoproteins and can therefore be used for the prophylaxis and the regression of atherosclerotic changes.

Inventors:
Uwe Heinert
Hans-Jochen Lang
Klaus Wild
Hans-Villi Janssen
Application Number:
JP2002565948A
Publication Date:
June 17, 2004
Filing Date:
December 07, 2001
Export Citation:
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Assignee:
Aventis Pharma Deutsche Land Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/34; A61K31/381; A61K31/40; A61K31/415; A61K31/417; A61K31/42; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4965; A61K31/50; A61K31/505; A61P1/00; A61P1/04; A61P1/10; A61P1/16; A61P3/06; A61P3/10; A61P3/12; A61P7/02; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P13/08; A61P13/12; A61P25/00; A61P33/14; A61P35/00; A61P39/00; A61P43/00; C07B61/00; C07D207/335; C07D213/38; C07D213/61; C07D231/12; C07D231/16; C07D233/54; C07D233/64; C07D237/08; C07D239/26; C07D241/12; C07D261/18; C07D277/28; C07D307/52; C07D333/20; C07D333/28; C07D333/42; C07D333/44; C07D521/00; C07D207/32; (IPC1-7): C07D207/335; A61K31/34; A61K31/381; A61K31/40; A61K31/415; A61K31/42; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4965; A61K31/50; A61K31/505; A61P1/04; A61P1/10; A61P1/16; A61P3/06; A61P3/10; A61P3/12; A61P7/02; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P13/08; A61P13/12; A61P25/00; A61P33/14; A61P35/00; A61P39/00; A61P43/00; C07D213/38; C07D213/61; C07D231/12; C07D231/16; C07D233/64; C07D237/08; C07D239/26; C07D241/12; C07D261/18; C07D277/28; C07D307/52; C07D333/20; C07D333/28; C07D333/42
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Hiroshi Sugimoto