Title:
Medicinal aerosol products
Document Type and Number:
Japanese Patent JP6178459
Kind Code:
B2
Abstract:
A pharmaceutical aerosol formulation suitable for oral and/or nasal inhalation including an anti-inflammatory steroid of the formula in which: R1 is 1-butyl, 2-butyl, cyclohexyl or phenyl and R2 is acetyl or isobutanoyl, in particular ciclesonide. The formulations also include hydrofluorocarbon propellants such as HFC 134a and/or 227, and cosolvent such as ethanol in an amount sufficient to solubilize the ciclesonide or related steroid (and various optional ingredients, such as surfactant). The formulations exhibit very desirable physical and chemical stability, as well as excellent delivery characteristics.
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Inventors:
Oliver, Martin Jay.
Fatania, Kanouem.
Scott, John S.
Müller, Helgert
Fatania, Kanouem.
Scott, John S.
Müller, Helgert
Application Number:
JP2016100499A
Publication Date:
August 09, 2017
Filing Date:
May 19, 2016
Export Citation:
Assignee:
3M INNOVATIVE PROPERTIES COMPANY
Takeda GmbH
Takeda GmbH
International Classes:
A61K31/58; A61K9/00; A61K9/12; A61K31/573; A61K47/06; A61K47/10; A61P11/06; A61P29/00; B65D83/14; B65D83/42; B65D83/54; C07J71/00
Domestic Patent References:
| JP4257599A | ||||
| JP2168964A | ||||
| JP9500855A | ||||
| JP4504566A |
Foreign References:
| WO1996029985A1 | ||||
| US4407481 |
Other References:
Expert Opinion on Investigational Drugs,1996年,Vol.5, No.7,p.871-884
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Masatoshi Takahashi
Kenichi Kato
Takashi Ishida
Tetsuji Koga
Masatoshi Takahashi
Kenichi Kato