MEDICINAL COMPOSITION CONTAINING TRI-AND TETRA-SUBSTITUTED-OXETAN AND TETRAHYDROFURAN AND ITS INTERMEDIATE

Japanese Patent JPH07196506

A

PURPOSE: To obtain a pharmaceutical composition usable for treating mammals suffering from not only autoimmune reactions and diseases but also susceptible fungal inflections, hyperproliferative skin diseases, allergic reactions and/or inflammations. CONSTITUTION: This pharmaceutical composition contains a compound represented by formula I [any one of A, B and C is O and the remaining two are CH2 or A is O; B is CH2 and C is a direct bond; Ar is thienyl, pyridyl, biphenyl or phenyl; Y is CH or N; Q is formula II to V P is a direct bond, CHR11 or CHR11 CHR12 ; W is NR5 , O or S(O)n [(n) is 0-2]; X is NO2 , P-NR6 R7 , formula VI, COR5 , Ar or OR3 ; (r) is 1 or 2; (t) is 0-3}, etc.; R1 is H or an alkyl substitutable with OH; R4 , R11 and R12 are each H, OH or an alkyl substitutable with OH; R3 is H, an alkyl or a (perhalo)alkanoyl; R6 and R7 are each H or a substitutable alkyl, alkoxy, etc., or together, form a five- or a six-membered substitutable heterocyclic group containing 1-4 heteroatoms; R5 is an alkyl, NH2 , a substitutable phenyl, etc.].

SAKUSENA ANIRU KEI
GIRIJIYABARABAAN BUIYOAA EMU
GANGURII ASHITO KEI
REEN DEINANASU EFU

JP21779294A

August 01, 1995

August 09, 1994

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SCHERING PLOUGH CORP

A61K31/41; A61K31/415; A61K31/425; A61K31/44; A61K31/443; A61K31/4433; A61K31/495; A61K31/52; A61K31/522; A61P29/00; A61P31/00; A61P37/08; C07D473/08; C07D405/06; C07D405/14; C07D409/14; C07D417/14; C07D473/10; C07D493/08; C07D521/00; (IPC1-7): A61K31/41; A61K31/415; A61K31/425; A61K31/44; A61K31/495; A61K31/52; C07D405/06; C07D405/14; C07D409/14; C07D417/14; C07D473/08

Kyozo Yuasa (4 outside)

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