Title:
MEDICINE COMPOSITION CONTAINING SUBSTITUTED HETEROCYCLIC DERIVATIVE
Document Type and Number:
Japanese Patent JP2000109431
Kind Code:
A
Abstract:
To obtain the subject composition showing activity as corticotropin release factor CFR antagonist, useful for treating mammalian chronic arthrorheumatism, deformed arthrosis, etc., by making the composition include a specific compound as an active ingredient.
This composition comprises an effective amount of a compound of formula I, formula II or formula III (a dotted line is an arbitrary double bond; A is N, a CR7 (R7 is H, a 1-4C alkyl or the like), an NR1R2 [R1 is H, a (substituted) 1-6C alkyl or the like; R2 is a 1-12C alkyl, an aryl or the like] or the like; D is N, OH or the like; E is N, CH or C; F is O, S or the like when F is bonded to E; G is H, a 1-4C alkyl or the like when G is bonded to E; R3 is H, a (substituted) 1-4C alkyl or the like; R5 is phenyl, naphthyl, thienyl or the like; Z is NH, O, S or the like} or its pharmacologically acceptable salt and a pharmacologically active carrier.
Inventors:
CHEN YUHPYNG L
Application Number:
JP30584799A
Publication Date:
April 18, 2000
Filing Date:
November 28, 1996
International Classes:
A61K31/435; A61K31/4355; A61K31/437; A61K31/44; A61K31/50; A61K31/505; A61K31/519; A61K31/52; A61K31/522; A61K31/54; A61P1/00; A61P1/04; A61P3/04; A61P3/08; A61P5/12; A61P5/14; A61P9/00; A61P9/04; A61P9/06; A61P9/12; A61P11/06; A61P11/08; A61P13/00; A61P13/02; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/20; A61P25/22; A61P25/24; A61P25/26; A61P25/28; A61P25/30; A61P29/00; A61P31/12; A61P35/00; A61P37/06; A61P37/08; C07D473/18; A61P43/00; C07D471/04; C07D473/34; C07D487/04; C07D491/048; C07D495/04; C07D498/04; C07D513/04; (IPC1-7): A61K31/437; A61K31/4355; A61K31/44; A61K31/50; A61K31/519; A61K31/52; A61K31/54; A61P1/00; A61P1/04; A61P3/04; A61P3/08; A61P5/14; A61P9/00; A61P9/04; A61P9/12; A61P11/06; A61P13/00; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P31/12; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D471/04; C07D473/34; C07D487/04; C07D491/048; C07D495/04; C07D498/04; C07D513/04
Attorney, Agent or Firm:
Kazuo Shamoto (4 outside)
